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Written by: Sarah Glinski, RD

Now more than ever, people are looking for ways to improve their physical and mental health. Diet is emerging as one of the strategies people can use to support their wellbeing. Many studies have found associations between diet and different aspects of physical health, and an emerging field of study called nutritional psychiatry is also starting to show associations between diet and mental health. Today, we’ll review some of the current evidence linking diet to physical and mental health so that you can provide evidence-based nutrition recommendations to your clients.


Many studies show the positive effects that a plant-based diet can have on health, including gut health,1,2 diabetes prevention3 and treatment,4 and cardiovascular disease.6


Research shows that plant-based diets may promote the development of a more diverse and stable gut microbiota.1 In particular, the polyphenols found in plant foods have been shown to increase populations of Bifidobacterium and Lactobacillus, which have been associated with anti-pathogenic and anti-inflammatory effects in the body.1 Fibre consumption is also associated with an increase in these beneficial bacteria.2

High fibre intake has also been shown to benefit the gut through the production of short-chain fatty acids (SCFAs). Research has shown that SCFAs have many beneficial effects, including improved immunity, protection of the blood-brain barrier, and regulation of intestinal function.1,2


A systematic review and meta-analysis found that following a plant-based diet was associated with a lower risk of developing type 2 diabetes. When healthy plant-based foods such as fruits, vegetables, whole grains, legumes, and nuts were consumed, this effect was even more pronounced.3

Another systematic review that looked at the association between plant-based diets and type 2 diabetes management found that a plant-based diet was associated with significantly better HbA1C levels compared with other diets.4 HbA1C levels are a marker of blood glucose control, and a lowered HbA1C is associated with better diabetes control.5

Overall, encouraging a diet rich in plant-based foods can be an effective way to improve diabetes management and lower HbA1C.3,4


There are several components of plant-based diets that are associated with reduced risk of cardiovascular disease.

A review found that replacing saturated fats (which are predominantly found in animal products) with unsaturated plant fats (such as canola oil, olive oil, avocado oil, and nuts and seeds) was associated with a reduction in LDL-cholesterol, without affecting HDL-cholesterol and triglycerides. The review also found that in both observational and randomized control trials, replacing saturated fats with unsaturated plant fats was associated with a lower risk of cardiovascular disease.6

This review also found that the plant sterols found in plant foods (e.g. seeds, nuts, vegetables) were associated with significant reductions in LDL-cholesterol without significantly affecting HDL-cholesterol, however, to meet the recommended 2 g per day to benefit from the LDL-lowering effect, consumption must be supplemented with foods fortified with phytosterol (e.g. soft margarine and yogurt).6


The field of nutritional psychiatry is an emerging field of study that looks at the associations between diet and mental health.

Emerging data are starting to show an association between a poor diet and worsening symptoms of anxiety and depression. However, it’s important to note that current epidemiological data on the connection between nutrition and mental health have not yet revealed mechanisms by which nutrition affects mental health.7

A meta-analysis published in 2017 found that diets low in animal foods and high in vegetables, fruits, whole grains, fish (many of which are high in omega 3 fatty acids), olive oil, low-fat dairy, and antioxidants were associated with a reduced risk of depression.8

A randomized controlled trial called the “SMILES” (Supporting the Modification of lifestyle in Lowered Emotional States) trial looked at the effect of nutrition on moderate to severe depression. The nutrition group received counselling sessions with a registered dietitian, while the control group received social support counselling sessions. The study found that people receiving nutrition counselling had reduced symptoms of depression, and that they consumed more whole grains, fruit, low-fat and unsweetened dairy, olive oil, pulses, and fish.9

While the results of the studies looking at the relationship between mental health and nutrition are promising, it’s too early to say whether nutrition is an effective treatment for mental illnesses such as anxiety and depression.

An important point to consider is that observational studies do not demonstrate cause and effect. It’s quite possible that diet quality was negatively impacted by mental health symptoms, or that poor diet was associated with other factors that could affect mental health, such as socioeconomic status.

Overall, further research is needed to determine mechanisms by which nutrition might impact mental health.


While many studies show an association between markers of physical health and components of a plant-based diet, it’s still too early to recommend dietary interventions as a treatment for mental illness.

However, despite the evidence being in its infancy, eating regular, wholesome meals is an important act of self-care that people can engage in when they’re struggling with negative mental health symptoms.

By combining diet, exercise, and other evidence-based strategies, we can encourage our clients to pursue a holistic picture of wellness that considers more than just the physical aspect of health.

For tips on how your clients can get started with plant-based eating, plus other strategies for promoting overall wellness, check out our new guide “5 Steps to Whole-Body Health.”
Sarah Glinski is a Registered Dietitian and holds a Bachelor of Science in Biology and a Bachelor of Science in Food and Nutrition Sciences. She has experience in a wide variety of clinical areas, including adult weight management, kidney disease, diabetes, gut health, food relationship, and oncology. Sarah is currently a member of the 2022 Becel Centre for Heart Health Steering Committee, a team of registered dietitians working to create practical and relevant content.


  1. Tomova A, Bukovsky I, Rembert E, Yonas W, Alwarith J, Barnard ND, Kahleova H. The Effects of Vegetarian and Vegan Diets on Gut Microbiota. Front Nutr. 2019 Apr 17;6:47. doi: 10.3389/fnut.2019.00047. PMID: 31058160; PMCID: PMC6478664. Sourced on October 19, 2022.
  2. Sakkas, H., et al. 2020. Nutritional Status and the Influence of the Vegan Diet on the Gut Microbiota and Human Health. Medicina (Kaunas). 56(2): 88 Sourced June 7, 2022.
  3. Qian F, Liu G, Hu FB, Bhupathiraju SN, Sun Q. Association Between Plant-Based Dietary Patterns and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis. JAMA Intern Med. 2019 Oct 1;179(10):1335-1344. doi: 10.1001/jamainternmed.2019.2195. PMID: 31329220; PMCID: PMC6646993. Sourced on October 19, 2022.
  4. Toumpanakis A, Turnbull T, Alba-Barba I. Effectiveness of plant-based diets in promoting well-being in the management of type 2 diabetes: a systematic review. BMJ Open Diabetes Research and Care 2018;6:e000534. doi: 10.1136/bmjdrc-2018-000534. Sourced on October 19, 2022
  5. Diabetes Canada Clinical Practice Guidelines Expert Committee. Diabetes Canada 2018 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Can J Diabetes. 2018;42(Suppl 1):S1-S325. Sourced on October 19, 2022.
  6. Trautwein EA, McKay S. The Role of Specific Components of a Plant-Based Diet in Management of Dyslipidemia and the Impact on Cardiovascular Risk. Nutrients. 2020 Sep 1;12(9):2671. doi: 10.3390/nu12092671. PMID: 32883047; PMCID: PMC7551487. Sourced on October 19, 2022.
  7. Adan RAH, van der Beek EM, Buitelaar JK, Cryan JF, Hebebrand J, Higgs S, Schellekens H, Dickson SL. Nutritional psychiatry: Towards improving mental health by what you eat. Eur Neuropsychopharmacol. 2019 Dec;29(12):1321-1332. doi: 10.1016/j.euroneuro.2019.10.011. Epub 2019 Nov 14. PMID: 31735529. Sourced on October 19, 2022.
  8. Li Y, Lv MR, Wei YJ, Sun L, Zhang JX, Zhang HG, Li B. Dietary patterns and depression risk: A meta-analysis. Psychiatry Res. 2017 Jul;253:373-382. doi: 10.1016/j.psychres.2017.04.020. Epub 2017 Apr 11. PMID: 28431261. Sourced on October 19, 2022.
  9. Jacka FN, O'Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, Castle D, Dash S, Mihalopoulos C, Chatterton ML, Brazionis L, Dean OM, Hodge AM, Berk M. A randomised controlled trial of dietary improvement for adults with major depression (the 'SMILES' trial). BMC Med. 2017 Jan 30;15(1):23. doi: 10.1186/s12916-017-0791-y. Erratum in: BMC Med. 2018 Dec 28;16(1):236. PMID: 28137247; PMCID: PMC5282719. Sourced on October 19, 2022.